Fig. 3: Antagonizing interactions between cytokines on target genes.
From: Systematic investigation of cytokine signaling activity at the tissue and single-cell levels
a, Co-regulation between IL-1β and other cytokines on target genes. Each dot represents a target gene. The x and y axes show the median logFC. Blue (co-enhance) represents targets with significant positive values on both axes (FDR < 0.05). Green (co-repress) represents targets with significant negative values on both axes. Orange (antagonize) represents targets with a significant positive score from one signal and a negative one from the other. Selected antagonized targets are labeled. b, Fractions of cytokine co-regulation type. For each cytokine pair and their targets, we counted the fractions of significant co-regulation in the three categories illustrated in a. c, Antagonistic relationships among cytokines on target genes. Each flat-end edge indicates that the first cytokine represses targets of the second one. The edge width is proportional to the number of antagonized targets. The node pie chart represents the in and out degrees. d, Antagonizing regulatory relationships between cytokines and anti-inflammatory signals. The heat map presents the number of target genes induced by a cytokine (row) but repressed by an anti-inflammatory signal (column). The similarities are shown with the hierarchical clustering trees using the Pearson correlation as the distance metric.
