Extended Data Fig. 7: Quantitative presentation of the impact of heterogeneity in culture medium on ratio of glucose uptake to lactate secretion in spheroids.
From: MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity
Left, Z-score heatmap and right, scatter diagram presenting the impact of six different media types on ratio of glucose (G) uptake to lactate (L) secretion (L/G ratio) in 5 established cell lines (N ≥ 2, n = 4). Indicative trendlines are presented in the scatter diagram with a dotted line (higher slope means a higher ratio of lactate secretion to glucose uptake (for example y = 2x; for the consumption of one glucose molecule 2 lactate molecules are produced)). Error bars indicate SD. Colors in scatter diagram present media type as in Fig. 3a; media types are ranked from higher nutrient (left) to lower nutrient (right) richness.
