Fig. 3: Culture media-induced transcriptional variation.
From: MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity
a, Principal component analysis of gene expression profiles from spheroids of four cancer cell lines cultured in six different medium types. b, Heatmap of Z-scores of all MSigDB hallmark gene sets identified by GSEA to be significantly enriched among the differentially expressed genes across the culture medium types in each cell line. Medium types are ranked from higher nutrient (left) to lower nutrient (right) richness.
