Extended Data Fig. 1: Homology modeling for SARS-CoV-2 proteins.

a, Homology models for SARS-CoV-2 nsp14 modeled from a high-quality template for from SARS-CoV-1 nsp14 (PDB 5C8S:D). The nsp14 homology model was retained and used in downstream computational predictions. b, Quality assessment on 11 SARS-CoV-2 models generated using the same method as the nsp14 model. For these 11 proteins solved crystal-structures for the SARS-CoV-2 protein were deposited into the PDB during submission and revision of this manuscript and validated the quality of the homology modelling. Assessment is based on the on root-mean-square deviation (RMSD) following alignment of the homology model and PDB structure using PyMol. c, Visual representation of the alignment between all homology models (magenta) against their available PDB structure (light blue). PDB IDs and chains used for both the homology template and the reference PDB structure are indicated.