Fig. 1: Principle of NSM. | Nature Methods

Fig. 1: Principle of NSM.

From: Label-free nanofluidic scattering microscopy of size and mass of single diffusing molecules and nanoparticles

Fig. 1

a, Artist’s rendition of the experimental configuration where visible light irradiates a nanochannel with a biomolecule inside, and where the light scattered from the system is collected in dark-field configuration. b, Schematic of light scattered by a single biomolecule. c, Schematic of light scattered by a nanochannel and the corresponding dark-field image. d, Schematic of light scattered by a nanochannel with a single biomolecule inside, and the corresponding differential dark-field image obtained by subtracting an image of the empty nanochannel from the image of the nanochannel with the biomolecule inside.

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