Extended Data Fig. 3: MIRA outperforms standard methodology for resolving cell state trajectories using accessibility data alone.
From: MIRA: joint regulatory modeling of multimodal expression and chromatin accessibility in single cells
Benchmarking results comparing MIRA to standard methodology of Seurat LSI + Slingshot in the indicated metrics of cell state trajectory inference using accessibility data alone. Top row shows ground truth scaffolds with scaffold difficulty increasing from left to right. No models solved the topology of the most difficult scaffold using accessibility alone so metric comparisons are shown for the other three scaffolds. See Extended Data Fig. 3 for description of metrics.
