Extended Data Fig. 5: Application of UTAG to various data and tissue types.
From: Unsupervised discovery of tissue architecture in multiplexed imaging
a) Discovery of tumor and stromal domains in CyCIF images of two types of lung cancer. The top row illustrates the intensity of three selected channels, while the bottom row displays the UTAG domains. Scale bars represent 200 µm. b) Discovery of structural domains in 15 intestine IMC images of COVID-19 infected patients30. The first row shows three channels of representative IMC images. The second row shows the corresponding segmented microanatomical domains. Scale bars represent 500 µm. c) Discovery of micro-anatomy in a dataset of 100 IMC images from pancreatic tissue of diabetes patients31. Each row represents a different region of interest. The first column shows three channels of IMC images. The second column shows identified cell types in the dataset. The third column shows supervised islet segmentation results from a trained random forest using manual labels available in the original publication. The fourth column shows unsupervised islet segmentation results from UTAG. Scale bars represent 200 µm.
