Extended Data Fig. 4: Matching and integration of cross-modality CyTOF and CITE-seq PBMC data.
From: Robust single-cell matching and multimodal analysis using shared and distinct features
MARIO integration of human PBMCs as measured by CyTOF and CITE-seq. (A) Performance of matching and integration during the sequential dropping of shared protein features. (B) Testing algorithm stringency between different methods. Increasing amounts of random spike-in noise was added to the data, and the matching accuracy and proportion of cells matched to X were quantified. (C) Testing algorithm stringency among different methods. Single-cell types in Y were completely removed before matching to X. The proportion of cells belonging to the deleted cell type in matched X cells was used to calculate the erroneous avoidance score. (D) t-SNE plots visualizing pre-integation and post-integration results across different methods.
