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Computational biology

Dissecting gene regulation with multimodal sequencing

Nature Methods volume 20, pages 1282–1284 (2023)Cite this article

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Recently proposed computational approaches explore casual links between chromatin and transcriptional changes that are provided by single-cell multimodal sequencing to bridge the knowledge gap in transcriptional regulatory control.

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Fig. 1: Principles of gene regulation, chromatin accessibility and multimodal single-cell sequencing.

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Acknowledgements

I thank C. Kuppe and S. Hayat (RWTH Aachen Medical Faculty) for comments and suggestions. This work was supported by the German Research Foundation (DFG) and the E:MED Fibromap Consortia from the German Ministry of Education and Science (BMBF).

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  1. Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen Medical Faculty, Aachen, Germany

    Ivan G. Costa

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  1. Ivan G. Costa
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Correspondence to Ivan G. Costa.

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Costa, I.G. Dissecting gene regulation with multimodal sequencing. Nat Methods 20, 1282–1284 (2023). https://doi.org/10.1038/s41592-023-01957-1

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