Extended Data Fig. 7: Comparison of scDVP to existing scRNAseq data (a-c) and FACS-based proteomics data (d-g).
From: Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome
a, Abundance normalized to 1 across 9 bins in Halpern et al. 6 (marker expression-guided bins), and this scDVP data (spatial bins). b, Intensity correlation of all hits (opaque dots, color according to cluster) and markers (black dots). Linear regression as dashed line, with Pearson correlation coefficient given over the figure. Grey line is the 45 degree line. c, Correlation coefficient for targets across all bins, with multiple testing adjusted p value. Top hits on either side are labeled in dark red, and marker proteins in orange. d, Abundance normalized to 1 across 8 bins in Ben-Moshe et al. 8 (marker expression-guided bins), and this scDVP data (spatial bins). e, Intensity correlation of all hits (opaque dots, color according to cluster) and markers (black dots). Linear regression as dashed line, with Pearson correlation coefficient given over the figure. Grey line is the 45 degree line. f, Correlation coefficient for targets across all bins, with multiple testing adjusted p value. Top hits on either side are labeled in dark red, and marker proteins in orange. g, A significant hit after gene set enrichment analysis on Pearson correlation coefficients, with normalized abundance of protein levels as heatmap colors.
