Extended Data Fig. 2: Statistical analysis of five-shape proteomes.
From: Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome
a, Volcano plot after an ANOVA over four sorted k means clusters (see Extended Date Fig. 1d). Statistically significant proteins (FDR < 0.05, n = 333 of 1652) with an absolute fold change of more than 0.5 are labeled. Colors indicate upregulation towards portal, or central zones. b, Heatmapping of statistically significant proteins in a. The blocks are separate by negative, or positive fold change. Protein expression as z-score of log2 transformed protein abundances. c,d, Five top significant terms (FDR < 0.05) after over-representation analysis enriched in peri-portal (c) or peri-central regions (d). See Supplementary table S2 for further reference.
