Extended Data Fig. 2: The impact of insufficient informative sites on Np estimation.
From: A statistical method for quantifying progenitor cells reveals incipient cell fate commitments
a. The schematic diagram shows the reconstructed error introduced by insufficient informative sites. When there is a loss of bifurcating nodes in the phylogenetic tree, it can lead to the overestimation of Np. b. In each panel, the performance of Np estimation is assessed for a specific number of informative sites, ranging from 10 to 1,000 sites. The x-axis represents the average Np obtained from 100 repeats, while the y-axis denotes the actual number of progenitors. The horizontal error bar indicates the interquartile range of Np estimates and the trendline fitted with a linear model (LM) is shown in blue. The Pearson′s correlation coefficients and the corresponding P-values obtained from two-sided t-tests are shown on the top-left corner of each panel.
