Extended Data Fig. 4: Examining the impact of reconstruction errors on the estimation of the number of progenitors for a focal cell type.
From: A statistical method for quantifying progenitor cells reveals incipient cell fate commitments
a. The diagram illustrates the process of dense sampling of the focal cell type (O1 in this case) under different levels of error rates. b. Each panel in the figure presents a comparison between two inference methods: TarCA and counting of the sheer number of monophyletic clades. The x-axis represents the sampling rate of the focal cell type within all its descendants. The y-axis displays the estimated number of progenitor cells and the corresponding estimation accuracy. The given error rate is indicated on the top of each panel. The results inferred using the sheer number of monophyletic clades are depicted with blue dots, while those inferred using TarCA are represented by orange dots. Each dot denotes the average level of the data. The error bars indicate the lower and upper quartiles of the data. Additionally, the red dashed line in each panel represents the actual number of progenitors of the focal cell type (O1 in this case). This line serves as a reference for assessing the accuracy of the estimation methods.
