Extended Data Fig. 5: Tumor cell PD-L1 up-regulates PDGFRA expression in B cells.
From: Mapping cellular interactions from spatially resolved transcriptomics data
(a) The expression of PDGFRA in B cells before and after anti-PD1 treatment, in the Bassez cohort (n = 31). (b) The spatial distribution of the different types of cells in the breast cancer Xenium dataset. (c) The spatial distribution of the CCCs that Spacia inferred in this dataset. We zoomed into one area to more clearly show the interactions (in black). (d) The distributions of the inferred βs by Spacia, across MCMC iterations, for the interactions between tumor PD-L1 and B cell PDGFRA, indicating the direction and the strength of the interaction between these two genes. (e) Scatterplot showing the βs from the Spacia analyses on both the MERSCOPE and Xenium breast cancer datasets for B cells. The fitted curves between the X axis and the Y axis are shown as solid lines, with the shading denoting 95% CI.
