Fig. 5: A use case of the Gene/Protein Lookup module for reported variants and protein features of MORC2. | Nature Methods

Fig. 5: A use case of the Gene/Protein Lookup module for reported variants and protein features of MORC2.

From: Genomics 2 Proteins portal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures

Fig. 5

a, The landing page of the Gene/Protein Lookup module shows an overview of the input gene (MORC2) information, followed by the protein sequence viewer displaying the aggregated protein features and variants on a selected transcript. b, To map variants on a structure, users can navigate to ‘variant to protein structure’ from the landing page of the Gene/Protein Lookup module, select a structure, and ‘click to view’, which launches the protein structure viewer. The viewer illustrates a structure of PDB 5OF9 with concurrent mapping of ClinVar PLP variants track (yellow) and protein feature; Binding site (black).

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