Extended Data Fig. 2: The sitemap of the Genomics 2 Proteins (G2P) portal.

From the home page, users can access the About, Documentation, Release Logs, APIs in the portal, and Feedback pages, available on the navigation bar at the top of the portal. There are two main modules in the portal: (1) Gene/Protein Lookup, accessible via searching by a human gene or protein name; (2) Interactive Mapping, accessible via secure Google sign-in upon clicking on the button displayed on the home page. The Gene/Protein lookup module has five submodules for protein sequence annotation, variant mapping to protein sequence, variant mapping to protein structure, gene to transcript to protein isoform mapping, and links to additional resources. The Interactive Mapping module has two submodules, for allowing users to start with any human gene or a protein structure to map user-uploaded data onto the target protein’s sequence and structure. The user input, data sources, visualization methods, and downloadable data formats within each submodule are listed in the figure.