Extended Data Fig. 2: Impact of graph normalization on the human chromosome 6 pangenome graph. | Nature Methods

Extended Data Fig. 2: Impact of graph normalization on the human chromosome 6 pangenome graph.

From: Building pangenome graphs

Extended Data Fig. 2

Comparison of the raw SEQWISH graph and its normalized version after SMOOTHXG. The normalization process locally compresses and simplifies the graph structure, resulting in lower node degree and graph depth. This effect is particularly pronounced in repetitive regions such as centromeres and satellite sequences. Node degree and graph depth are visualized for both the original SEQWISH graph and the normalized graph.

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