Extended Data Fig. 5: Coverage of the nucleolar proteome during the 47S O-MAP labeling time course.
a, Volcano plots for each 47S O-MAP labeling point, calculated relative to the 7SK/10-min label condition. Enrichment of nucleolar proteins derived from our k-medoid analysis (Fig. 3h–j; Supplementary Fig. 10) are highlighted in pink. Significance cutoffs were assigned at padj ≤ 0.05 and Fold Change (47S/7SK) ≥ 2.0. (dotted lines). Benjamini Hochberg corrected p-values (FDR) b, Table summarizing the recovery of the nucleolar proteome at each labeling time point. Note that coverage appears to plateau at 10 min.
