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Mapping voltage activity in a live mouse brain in 3D using confocal light field microscopy

Voltage imaging, a promising technique for directly recording neuronal activity, faces barriers to broad application due to current limitations in compatible imaging modalities. Our team introduces an advanced confocal light field microscopy method enabling high-throughput, rapid and low-noise 3D voltage imaging in awake mice.

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Fig. 1: Schematic of the confocal LFM and an example of volumetric voltage imaging of neuronal populations in the cortex of an awake mouse.

References

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This is a summary of: Bai, L. et al. Volumetric voltage imaging of neuronal populations in the mouse brain by confocal light-field microscopy. Nat. Methods https://doi.org/10.1038/s41592-024-02458-5 (2024).

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Mapping voltage activity in a live mouse brain in 3D using confocal light field microscopy. Nat Methods 21, 1992–1993 (2024). https://doi.org/10.1038/s41592-024-02459-4

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