Fig. 1: Schematic workflow of the construction of the XL-MS standard. | Nature Methods

Fig. 1: Schematic workflow of the construction of the XL-MS standard.

From: Proteome-scale recombinant standards and a robust high-speed search engine to advance cross-linking MS-based interactomics

Fig. 1

Proteins were allocated into 32 interaction groups with 8 proteins each. Within the interaction groups, proteins were cross-linked pairwise in all possible combinations, resulting in 28 PPIs per interaction group and 896 PPIs in total. All cross-linked samples were merged before digestion. Created with BioRender.com.

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