Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Biophysics

Marrying mechanics with spatial transcriptomics

Nature Methods volume 22, pages 658–659 (2025)Cite this article

Subjects

A method infers tension from spatial transcriptomic data on single cells in tissue context.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Pipeline for integration of data on morphology, state and mechanics of single cells in issue context.

References

  1. Pijuan-Sala, B. et al. Nature 566, 490–495 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Nowotschin, S. et al. Nature 569, 361–367 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Lohoff, T. et al. Nat. Biotechnol. 40, 74–85 (2022).

    Article  CAS  PubMed  Google Scholar 

  4. Hallou, A., He, R., Simons, B. D. & Dumitrascu. B. Nat. Methods https://doi.org/10.1038/s41592-025-02618-1 (2025).

  5. Rauzi, M., Verant, P., Lecuit, T. & Lenne, P. F. Nat. Cell Biol. 10, 1401–1410 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Samarage, C. R. et al. Dev. Cell 34, 435–447 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Yamashita, S., Tsuboi, T., Ishinabe, N., Kitaguchi, T. & Michiue, T. Sci. Rep. 6, 28535 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Noll, N., Streichan, S. J. & Shraiman, B. I. Phys. Rev. X 10, 011072 (2020).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Dahmann, C., Oates, A. C. & Brand, M. Nat. Rev. Genet. 12, 43–55 (2010).

    Article  Google Scholar 

  10. Batlle, E. & Wilkinson, D. G. Cold Spring Harb. Perspect. Biol. 4, a008227 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Alexandre Francou, Woonyung Hur & Anna-Katerina Hadjantonakis

  2. Center for Studies in Physics and Biology, The Rockefeller University, New York, NY, USA

    Woonyung Hur

Authors
  1. Alexandre Francou
    View author publications

    Search author on:PubMed Google Scholar

  2. Woonyung Hur
    View author publications

    Search author on:PubMed Google Scholar

  3. Anna-Katerina Hadjantonakis
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Anna-Katerina Hadjantonakis.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Francou, A., Hur, W. & Hadjantonakis, AK. Marrying mechanics with spatial transcriptomics. Nat Methods 22, 658–659 (2025). https://doi.org/10.1038/s41592-024-02491-4

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41592-024-02491-4

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing