Extended Data Fig. 8: Summary of all datasets analyzed in this study.

a, Schematic of the global methylation dynamics over the life time of an individual, created using BioRender.com. Our study analyzed datasets across all three key stages of methylation dynamics, including two global de-methylation waves before birth and a stable period after birth. b, Bar plot comparing lineage accuracies from raw similarity or corrected (cell-type-signal removed if needed) similarity across all datasets analyzed in this study. c, Bar plot comparing lineage accuracies from using all 500-bp bins, selected genomic regions, all single-CpG sites, or from a randomized cell ordering, across all datasets analyzed in this study. The accuracies from selected-region and single-CpG methods are significantly higher than those from randomization, each with a p-value < 0.0005.