Extended Data Fig. 5: Clustering results for a mouse olfactory bulb spatial transcriptomics dataset.
From: Resolving tissue complexity by multimodal spatial omics modeling with MISO
a, Clustering results from MISO, MUSE, and SpatialGlue. b, H&E-stained histology image of analyzed tissue section with layer annotation. The MISO results align well with the annotation, assigning clusters to each of the annotated layers. MUSE was not able to accurately localize clusters to the annotated layers, and instead separated spots in the upper region of the tissue section from those in the lower region. c, RNA and image ICC distributions across all clusters and features for each method (n = 400 ICC values for each group). The mean ICC for each method and each modality is printed on the corresponding box plot. Test statistics and p-values were obtained using one-sided (<,>) or two-sided (≈) t-tests. Box plots: center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; points, outliers.
