Extended Data Fig. 1: Intraclass correlation coefficient (ICC) results for all datasets provided in Figs. 2-5 that were evaluated using MISO, MUSE, and SpatialGlue.
From: Resolving tissue complexity by multimodal spatial omics modeling with MISO
The mean ICC for each method and each modality is printed on the corresponding box plot. Test statistics and p-values were obtained using one-sided t-tests (n = 1250 ICC values for each group). For a vast majority of the modalities across all datasets, the MISO clustering results produced a higher ICC compared to the other methods. The only instance in which the MISO ICC was lower was for the RNA modality in the mouse hippocampus spatial transcriptomics and metabolomics dataset, where the ICC for SpatialGlue surpassed that of MISO. The likely cause of this is that, because the RNA data was of low quality, MISO did not use the RNA-specific terms in clustering, and only accounted for this modality through the RNAxImage and RNAxMetabolite interaction terms. Box plots: center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; points, outliers.
