Extended Data Fig. 5: Clustering of mouse cerebral cortex cells based on Paired-Damage-seq RNA profile.
From: Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability
a, Dot plots showing the expression of marker genes for each mouse brain cell type measured from Paired-Damage-seq RNA profiles. The size of the dots represents the fraction of cells positively detect the transcripts and the color of the dots represents the average levels. b, UMAP co-embedding of single nuclei transcriptomic profile from Paired-Damage-seq and reference snRNA-seq datasets on mouse motor cortex regions. c, Heatmap showing the overlap coefficients between cell type annotations based on Paired-Damage-seq RNA profiles and the previously published snRNA-seq dataset. d, Line plots showing the normalized DNA signal enrichments of ATAC-seq, non-targeting tagmentation control and Paired-Damage-seq DNA signals on ATAC-seq peak regions of mouse brain.
