Extended Data Fig. 9: Major signature contributions from urothelial cancer patients’ tumors measured through whole-genome sequencing. | Nature Methods

Extended Data Fig. 9: Major signature contributions from urothelial cancer patients’ tumors measured through whole-genome sequencing.

From: Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling

Extended Data Fig. 9

Top: total mutation counts per sequenced tumor. Bottom: signature contributions. Trinucleotide frequencies were fit to the entire COSMIC database (version v.3.3). When a patient had two or more tumors (B01, B04, B15, B16, B17, B18, B19), we measured signature contributions of mutations that were present in two or more tumors and thereby likely reflect mutations that arise earlier in tumor evolution.

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