Fig. 2: Performance evaluation of PTM-Mamba across diverse PTM-related tasks.
From: PTM-Mamba: a PTM-aware protein language model with bidirectional gated Mamba blocks
a, Disease association prediction for PTM modified sequences, evaluated across accuracy, precision, recall, F1, MCC, area under the precision–recall curve (AUPRC) and area under the receiver operating characteristic curve (AUROC). b, Druggability prediction of PTM modified sequences, evaluated across the same metrics. c, Prediction of PTM effects on PPIs, using PTMint data to classify whether a PTM induces or inhibits an interaction. All benchmarks in a–c were performed with replicates (n = 5). d, Visualization of the predicted logits for zero-shot PTM discovery. Rows denote different amino acids in the format of ‘Uniref-accession-id (amino-acid position)’, and columns denote the logit value of the PTMs. Schematic in panel c created using BioRender.com.
