Extended Data Fig. 10: Rare biological behaviors of Lyso-Mito interactions revealed by Meta-rLLS-VSIM imaging. | Nature Methods

Extended Data Fig. 10: Rare biological behaviors of Lyso-Mito interactions revealed by Meta-rLLS-VSIM imaging.

From: Fast-adaptive super-resolution lattice light-sheet microscopy for rapid, long-term, near-isotropic subcellular imaging

Extended Data Fig. 10

a,b, Time-lapse max intensity projections (upper row) and surface rendering (lower row) of mitochondria and lysosomes showcasing that a moving Lyso-generated mechanical force to induce mitochondrial fission by pulling out (a) or pushing against (b) Mito membrane. c, Time-lapse max intensity projections (upper row) and surface rendering (lower row) of mitochondria and lysosomes showcasing a mitochondrion reformed itself from tubular into doughnut-like structure that corralled the Lyso to regulate its movement. Scale bar, 2 μm.

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