Fig. 3: Tissue annotation using bulk RNA-seq data.
From: A visual–omics foundation model to bridge histopathology with spatial transcriptomics
a, Schematic illustration of tissue annotation using H&E image and reference bulk RNA-seq data from different sources, with OmiCLIP paired image and transcriptomic embeddings. b, Histology WSIs of breast cancer, heart failure and normal breast samples. The major tumor regions, fibroblast cell-enriched regions and adipose regions are annotated by pathology experts in black lines. Heat map shows the similarity of WSIs to the corresponding reference bulk RNA-seq of tumor, fibroblast and adipose, respectively. The color of the heat map reflects the similarities between WSIs and reference bulk RNA-seq data, with red indicating high similarity and blue indicating low similarity. CLAM attention heat maps were generated using CLAM with default parameters.
