A new approach sheds light on the biological features learned by protein language models, promising greater interpretability for unsupervised sequence learning.
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Acknowledgements
We thank E. Simon for insightful discussions.
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All authors are current or former employees, contractors or executives of Profluent Bio Inc. and may hold shares in Profluent Bio Inc.
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Ruffolo, J.A. What does a language model know about proteins?. Nat Methods (2025). https://doi.org/10.1038/s41592-025-02837-6
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DOI: https://doi.org/10.1038/s41592-025-02837-6
