Fig. 1: FlexConsensus analysis resulting from comparing the estimations of HetSIREN and CryoDRGN for the IgG-RL dataset included in CryoBench11.
From: Merging conformational landscapes in a single consensus space with FlexConsensus algorithm
The image shows both the original consensus space derived from the two methods and the consensus space obtained by keeping only those particles in the consensus space that are significantly similar. The first two landscapes displayed in the image correspond to the unfiltered consensus spaces obtained with FlexConsensus. Following these spaces, we include the plot with the different P values obtained from the permutation test when filtering an increasingly larger number of samples, highlighting the threshold proposed by the test (which corresponds to a P value of 0.05 from the one-sided test). Below the previous plot, the permutation distribution of distances for the selected threshold is included, showing that most of the measurements computed from the random labeling fall below it. Lastly, the figure shows the consensus spaces obtained after applying the threshold proposed by the test, showing a more similar distribution of states. SWD, sliced Wasserstein distance.
