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Using comparative connectomics to understand variability and evolution in neural circuits

Nature Methods volume 22, pages 2481–2483 (2025)Cite this article

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Advances in connectomics are enabling the mapping of connectomes across individuals, sexes or species. Multiple comparisons enable the categorization of differences in these wiring diagrams as either technical or biological variability, or those that might impact circuit function. Testing these predictions experimentally will help us understand how evolution operates in neural circuits.

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Fig. 1: Comparison of connectomes across development, sexes and species.

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  1. Department of Zoology, University of Cambridge, Cambridge, UK

    Marta Costa

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  1. Marta Costa
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Correspondence to Marta Costa.

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Costa, M. Using comparative connectomics to understand variability and evolution in neural circuits. Nat Methods 22, 2481–2483 (2025). https://doi.org/10.1038/s41592-025-02946-2

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