Supplementary Figure 16: The distribution of p values following reiteratively removing 2 TD men and 2 ASD men from the startle analysis
From: Altered responses to social chemosignals in autism spectrum disorder
The red line represents the p value following removing the women (2 TD and 2 ASD) from the startle analysis. To ask whether the effects of HEX on startle were gender-specific we excluded the women from analysis of that one study (2 TD, 2 ASD). The ANOVA revealed a near significant interaction of Condition X Group (F1,26 = 4.1, p = 0.054). Notably, this analysis resulted in decreased significance compared with the original analysis that included all participants. In turn, this has now reduced our sample size by 4 participants. To estimate whether this was the effect of gender or the effect of sample size, we reiteratively removed 4 men (2 TD and 2 ASD) 1000 times, and tested the distribution of p values. We obtained a mean of p = 0.016 ± 0.012, which is indeed significantly different from 0.054. Thus, we conclude that the effect was in the same direction in men and women, but stronger in women that participated in the experiment.
