Fig. 6: Identification of genetic suppression of TDP-43 toxicity in Drosophila disease models of ALS.
From: TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
a,b, Overexpression of human TDP-43WT and TDP-43G298S in Drosophila leads to neurodegeneration in the adult retina (a) and impairment in larval locomotor function (b). GMR GAL4 and D42 GAL4 driver lines were used for expression in the retina and motor neurons, respectively. w1118 was used as a control fly line. Loss-of-function mutations in several Drosophila Nup genes rescue the phenotypes caused by TDP-43 pathology. Graph represents quartiles (boxes), 50th percentiles (center lines) and range (whiskers) in b (dots represent, for D42 × w1118: n = 26, others: n = 30 animals; *P < 0.05, ***P < 0.001, two-way ANOVA), Bonferroni’s post hoc test. Full statistical details are provided in Supplementary Table 4.
