Fig. 7: Nuclear pore pathology is present in fALS and sALS brain tissue with pTDP-43-positive inclusions.
From: TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
a, Immunohistochemical staining of Nup205 in human motor cortex was done once on samples from five control, ten sALS, seven C9-ALS, one SOD1-ALS and two TDP-ALS subjects, with similar results within groups. Scale bar: 100 μm. b, Double staining for pTDP-43 (blue) and Nup205 (brown) in motor cortex of TDP-ALS. Arrow indicates colocalization. Scale bar: 50 μm. c, pTDP-43 staining (left) and double staining of pTDP-43 (blue) and Nup205 (brown) (right) in TDP-ALS hippocampus. Arrow indicates colocalization. Scale bar: 50 μm. d, Immunohistochemical staining of Nup205 in motor cortex and cerebellum was done once on five control, five sALS and the TDP-ALS cases, with similar results within groups. Scale bar: 100 μm.
