Supplementary Figure 9: Simultaneous activation of 10 genetic elements including 8 genes and 2 lncRNAs in the liver via hydrodynamic injection of dual-AAV vectors. | Nature Neuroscience

Supplementary Figure 9: Simultaneous activation of 10 genetic elements including 8 genes and 2 lncRNAs in the liver via hydrodynamic injection of dual-AAV vectors.

From: In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice

Supplementary Figure 9

(a) Experimental flow of gene activations in the liver of SPH transgenic mice. (b) Schematic of the AAV-10-sgRNA-array and AAV-Alb-Cre. (c) Simultaneous activation of 8 genes and 2 lncRNAs (n = 2 mice). SPH mouse injected with vehicle serves as a control.

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