Supplementary Figure 6: Developmental changes in genes encoding 5-HT3AR and nAChRs within 5-HT3AR+ interneurons.
From: Inhibitory circuit gating of auditory critical-period plasticity
Normalized expression (mean ± SEM) of Htr3a, Chrna4, Chrna7, and Chrnb2 genes encoding 5-HT3AR and nAChR subunits (α4, α7, and β2) within 5-HT3AR-expressing interneurons from primary auditory cortex (A1) in mice aged postnatal day (P) 11 and P20. (Normalized quantity Htr3a: P11 = 0.74 ± 0.12 (95% CI, 0.37, 1.11), P20 = 1.87 ± 0.58 (95% CI, 0.01, 3.73), z = 1.01, P = 0.31; Normalized quantity Chrna4: P11 = 1.52 ± 0.03 (95% CI, 1.43, 1.62), P20 = 1.27 ± 0.07 (95% CI, 1.05, 1.48), z = −2.17, P = 0.03; Normalized quantity Chrna7: P11 = 1.08 ± 0.07 (95% CI, 0.85, 1.32), P20 = 1.22 ± 0.05 (95% CI, 1.06, 1.37), z = 1.30, P = 0.19; Normalized quantity Chrnb2: P11 = 1.02 ± 0.09 (95% CI, 0.73, 1.31), P20 = 1.00 ± 0.05 (95% CI, 0.83, 1.18), z = 0, P = 1.00; Mann-Whitney U tests, two-tailed, n = 4 mice each). *P < 0.05.
