Supplementary Figure 10: A topographic organization of 5-HT3AR+ interneurons.
From: Inhibitory circuit gating of auditory critical-period plasticity
Imaging of 5-HT3AR interneurons expressing the genetically-encoded calcium indicator (GCaMP6f) using 5-HT3AR-Cre x Ai95 mice. (a) Schematic of an auditory thalamocortical slice illustrates the lateral (1) and medial (6) positions stimulated within the ventral medial geniculate body (MGBv). (b) Average normalized traces (ΔF/F) across all mice (n = 3 mice) within layer (L) 1 locations of primary auditory cortex (A1) to stimulation of MGBv positions 1 and 6. (c) Mean peak responses (norm. ∆F/F) within L1 of A1 to stimulation of MGBv positions 1 and 6 across all mice (n = 3 mice). Black arrows indicate the rostro-caudal location of peak responses within L1.
