Supplementary Figure 3: A slight increase in IBA-1 immunoreactivity is found in postmortem brains of ALS patients with SOD1 mutations, compared to samples from control or sALS patients. | Nature Neuroscience

Supplementary Figure 3: A slight increase in IBA-1 immunoreactivity is found in postmortem brains of ALS patients with SOD1 mutations, compared to samples from control or sALS patients.

From: Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

Supplementary Figure 3

Representative images from cerebellum (a-c), hippocampus (d-f), and thalamus (g-i) of a control patient (a, d, g), a sporadic ALS patient (b, e, h), and a fALS patient with a SOD1 mutation (c,f,i) immunostained with IBA-1 (red) show slightly higher levels of reactive microgliosis in samples from patients with mutations in SOD1, but not in sporadic ALS or controls. Staining was done on brain regions from 4 control patients, 3 sporadic patients, and 3 patients with a SOD1 mutation with similar results. Scale bars = 100 μm.

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