Supplementary Figure 8: Electrical advantages of compound connectivity; related to Fig. 8.
From: Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites
(a) Comparison between a compound synapse pair and the 2x synapse configuration across the entire dendritic morphology of the pyramidal cell. Note that the advantage of compound connectivity is present in the oblique dendrites to the same extent as the tuft dendrites (compare to results from Fig. 8). (b) Left, comparison between the compound synapse configuration and the scaled single input condition (note: the compound synapse pair is the same data from Fig. 8c). Right, in order to produce the same peak dendritic voltage change as the scaled single input in the dendritic shaft, the synaptic conductance in the “2x synapse” condition needs to be increased three-fold. (c) Electrical advantages of the different compound synapse configurations observed by ssTEM. Left, the recording configuration of the ball-and-stick model. Right, peak voltage changes in spine 1, spine 2, and in the dendritic shaft for the 2x configuration and for various different compound synapse configurations. The dashed line is the maximal dendritic depolarization in the 2x synapse configuration.
