Fig. 4: The HIC1 motif is enriched in both H4K16ac gains during aging and H4K16ac losses in AD.
From: Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease
a,d, Scatter plot showing H4K16ac peak enrichment (measured as AUC) between (a) Young and Old and (d) Old and AD subjects for peaks detected in each of the three groups. Blue dots represent peaks with significant H4K16ac changes (P < 0.05, Welch’s t test, two-sided). For graphical representation, 1,000 randomly chosen points are shown in each case. b,c,e,f, Top DNA motifs from SeqPos analysis are shown for peak regions with significant (P < 0.05, Welch’s t test, two-sided) H4K16ac (b) gains or (c) losses in aging (Young-to-Old comparison) and H4K16ac (e) gains or (f) losses in AD (Old-to-AD subjects comparison; within top 6 DNA motifs by significance) within 1 kb from TSS.
