Fig. 5: Three classes of H4K16ac changes detected in AD.
From: Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease
a–c, Peak schematic of the three classes of H4K16ac changes in AD: (a) age-regulated, (b) age-dysregulated and (c) disease-specific. Each class is further separated into two subclasses based on H4K16ac gains or losses in AD. The number of significant gains or losses (P < 0.05, one-way ANOVA) in each defined subclass is reported below the schematic. d–f, Box-plots of H4K16ac enrichment in each subclass reported in a–c. Boxplots show minimum, first quartile, median (center line), third quartile and maximum. Outliers are represented as black dots. g–i, Representative UCSC Genome browser track views of H4K16ac changes defined above. Chr, chromosome. j–l, Bar plot of top eight GO terms (Biological Process and Cellular component; DAVID Bioinformatics Resources v6.7) in each of the three classes of H4K16ac changes with at least 20 genes per term and false discovery rate (FDR) < 10%.
