Supplementary Figure 1: ACBM walking phenotypes.
From: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
(a) Uncropped agarose gel of genotyping PCR used in figure 1b. (b) Automated continuous behavioral monitoring of walking behavior from 4 to 11.5 months of age separated by sex (n = 5 mice per genotype). Male mice; 4 months: interaction *P = 0.001; 6 months: interaction *P = 0.003; 7.5 months: interaction *P < 0.0001; 10 months: interaction *P < 0.0001; 11.5 months: interaction *P < 0.0001. Female mice; 4 months: interaction *P = 0.034; 6 months: n.s. interaction P = 0.138; 7.5 months: n.s. interaction P = 0.334; 10 months: interaction *P < 0.0001; 11.5 month: interaction *P < 0.0001; repeated measures two−way ANOVA. Error bars represent mean ± s.e.m.
