Supplementary Figure 4: Response changes during learning. | Nature Neuroscience

Supplementary Figure 4: Response changes during learning.

From: Distinct learning-induced changes in stimulus selectivity and interactions of GABAergic interneuron classes in visual cortex

Supplementary Figure 4

(a, d) Average response profiles in response to vertical (a) and angled grating stimulus (d) of all cells from each cell class before (dashed line) and after (solid line) learning. Vertical dashed line indicates grating onset. Shaded area represents SEM, here and elsewhere. N = 1249, 132 PV, 58 SOM and 175 VIP cells here and below. (b, e) Top: Difference between post-learning and pre-learning response profiles in response to the vertical (b) and angled (e) grating stimuli for all cells of different cell classes. Responses were baseline corrected before subtracting (baseline -.5 to 0 sec before stimulus onset), are shown aligned to grating onset (dashed line), and color coded for Δ(ΔF/F). Bottom: average responses of cells from the top, middle and bottom 10th percentiles of the response differences shown on top. (c, f) Fractions of cells in which the response amplitude to the vertical (c) and angled (f) grating stimuli increased, decreased, or showed no difference from pre-to post-learning in the period 0-1 s from stimulus onset.

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