Supplementary Figure 2: The V1bR antagonist SSR149415 delayed the progression of morphine tolerance in rats. | Nature Neuroscience

Supplementary Figure 2: The V1bR antagonist SSR149415 delayed the progression of morphine tolerance in rats.

From: Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance

Supplementary Figure 2

The antagonist (100 pmol) was administered into the lateral ventricle 10 min before daily morphine administration (10 mg/kg/day, s.c.) for 5 days. The tail flick test was performed 30 min after the morphine administration. Antagonist treatment had a significant effect on %MPE (In two-way ANOVA, F1,45 = 7.64. P = 0.0082 for antagonist treatment as indicated by *. F2,45 = 25.726. P < 0.0001 for time course. Significant interaction between antagonist treatment and time course was observed. F2,45 = 8.429. P = 0.0008). Graphs represent the mean ± S.E.M.

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