Supplementary Figure 2: Overlap of association results for our five traits. | Nature Neuroscience

Supplementary Figure 2: Overlap of association results for our five traits.

From: A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

Supplementary Figure 2

For each of the five AD-related traits shown in the figure, a univariate transcriptome-wide association study (TWAS) was conducted. To quantify the proportion of genes whose expression is associated with each pair of AD traits, the following procedure was used: for each trait i, we used the 0.05 FDR threshold to identify genes whose expression associate with trait i. In this case, trait i is the “discovery” sample. Then, we used the pi1 statistic to quantify the proportion of the 0.05 FDR genes that are deemed as true positives for trait j, and so trait j is the “replication” sample. In summary, element (i,j) in this figure represents the pi1 statistic when assessing the 0.05 FDR genes (identified in the discovery sample) from trait i (rows) in the replication sample (trait j)(columns).

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