Supplementary Figure 8: Simultaneous recordings of sharp-wave and ripple oscillations in CA1 and CA3 regions.

a) Recording of sharp-wave and ripple events in the CA1 region of the hippocampus. Schematic (left) depicts the position of the recording electrode as it is moved across lamina. Representative events filtered in either the 4–20 Hz sharp-wave band (violet) or the 150–250 Hz ripple band (grey). Note the presence of ripple oscillations in the pyramidal layer, and the reversal of sharp-wave polarity across the pyramidal layer in CA1. b) Concurrently recorded sharp-wave and ripple oscillations in the CA3 region from the same experiment. Note both sharp-wave and ripple oscillations can be detected in the CA3 pyramidal layer. c) Summary data for all sharp-waves recorded in the CA3 region. Left, distribution and cumulative percentage of sharp-wave inter-event intervals. Inset; representative example trace of a sharp wave cluster. Middle, distribution and cumulative percentage of sharp-wave event amplitudes. Inset, representative individual sharp-wave event where amplitude measurement is indicated by orange arrow. Right, distribution and cumulative percentage of sharp-wave event durations. Inset, representative individual sharp-wave event where duration measurement is indicated by red arrow.