Supplementary Figure 7: Released amount of Abeta40 and Abeta42 ratio in week 9.
From: A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease
Conditioned media from each individual device from 3D Neu + AC (blue), 2D Neu + AC AD (purple) and 3D Neu + AC AD (red) were measured and quantified by dividing Abeta40 or 42 at week0 by showing the released amount of soluble Abeta40 and Abeta42 in week 9. Graph showed increased amount of soluble Abeta40 in conditioned media while Abeta42 was slightly decreased by comparison with Week 0. Two-way ANOVA revealed significant differences in between 3D Neu + AC vs 3D Neu + AC AD and 2D Neu + AC AD vs 3D Neu + AC AD (all **p < 0.0001, F (2, 8) = 100.8), All experiments were repeated ≥ 3 times. Each data point is the average ± SEM. of five different devices.
