Supplementary Figure 11: CCL2 dependent recruitment of microglial cells.
From: A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease
Microglial cell recruitment significantly reduced in AD neuron/astrocyte co-culture condition with neutralizing Anti-CCL2. Two-way ANOVA revealed significant differences in between 2D Neu + AC + MG AD vs 2D Neu + AC + MG AD + Anti-CCL2 (**p < 0.0020, F (1, 4) = 51.09) and 3D Neu + AC + MG AD vs 3D Neu + AC + MG AD + Anti-CCL2 (***p < 0.0007, F (1, 4) = 86.39), All experiments were repeated ≥ 3 times. Each data point is the average ± SEM. of five different devices.
