Supplementary Figure 7: Behavioral controls for Bar^ESR1-hM4Di and Bar^CRH-hM4Di chemogenetic inhibition.

a, Total distance traveled during the assay shown in Fig. 7a-e for Bar^ESR1-hM4Di mice (n = 8). Thin dotted lines are individuals, thick black line is mean ± s.e.m. p = 0.58 Friedman’s test. b, Same as (b), but for total female urine odor sniffing time. p = 0.021 Friedman’s test, *day 4 saline p = 0.012 Dunn-Sidak posthoc differences from CNO day 1. c, Analysis of Bar^CRH-hM4Di mice (n = 10) injected with either saline or CNO on consecutive days prior to a 2-hour urination assay, similar to that previously published¹⁵ and which is not limited to odor-evoked, voluntary urination. *p = 0.049, Mann-Whitney U test for difference between CNO and saline treatment days.